Your doctor may need to change the doses of your medications or monitor you carefully for side effects. If you have recently had a head injury or a heart attack. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. 45, Migranal), ergoloid mesylates (Hydergine), ergotamine (in Cafergot, in Migergot), methylergonovine (Methergine), methysergide (Sansert; no longer available in the U.S.), and pergolide (Permax; no longer available in the U.S.); medications for high blood pressure, heart failure, or an irregular heartbeat. We study millions of patients and 5,000 more each day. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Some products that may interact with this drug include: drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), riociguat. This content does not have an English version. Isosorbide mononitrate belongs to the group of medicines called nitrates. Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. Thirty percent of the patients never experienced headache from the given dosages. 55 ratings on Drugs.com. If you have an eye condition called glaucoma. Click here for an email preview. To provide you with the most relevant and helpful information, and understand which Consult your doctor for more details. Portions of this document last updated: Feb. 01, 2023. McGraw Hill; 2022. https://accessmedicine.mhmedical.com/search. Some brands of isosorbide mononitrate tablets should be taken two or three times a day. Unable to load your collection due to an error, Unable to load your delegates due to an error. Seek alternatives to the CYP3A4 substrate when possible. This medication belongs to a class of drugs known as. Truven Health and GoodRx make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Accessed Sept. 7, 2022. Background: The extended-release tablet usually is taken once daily in the morning. If you do not remember until your next dose is nearly due, then leave out the forgotten dose and take your next dose when it is due. Almost 70% of older adults use them. This medicine is for you. other information we have about you. It works to relax your blood vessels. Isosorbide mononitrate should not be used in patients with severe anaemia, severe hypotension, closed angle glaucoma or severe hypovolaemia.Isosorbide mononitrate may give rise to postural hypotension and syncope in some patients. https://naturalmedicines.therapeuticresearch.com. The list below does not include all possible drug interactions with isosorbide mononitrate (Monoket). Isosorbide may not work as well after you have taken it for some time or if you have taken many doses. Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide dinitrate, nitroglycerin); or if you have any other allergies. Accessed Sept. 7, 2022. Accessed Sept. 7, 2022. 41% of reviewers reported a positive effect, while 50% reported a negative effect. If headaches continue or become severe, tell your doctor promptly. Glyceryl trinitrate (GTN) is commonly prescribed for this. Zhonghua Yi Xue Za Zhi (Taipei). The extended-release capsule usually is taken once daily. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. 1994 Jan;15(1):108-13. doi: 10.1093/oxfordjournals.eurheartj.a060361. Saper RB. https://naturalmedicines.therapeuticresearch.com. Consult your doctor for more details. The extended-release tablet usually is taken once daily in the morning. To avoid this problem, get up slowly, resting your feet on the floor for a few minutes before standing up. ask your doctor about the safe use of alcoholic beverages while you are taking isosorbide. But only about 25% of people who take herbal supplements tell their health care providers. Accessed Sept. 7, 2022. Headaches can be a sign that the medicine is working, and they might lessen with continued use of the medication. Evening primrose. Accessed Sept. 7, 2022. Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. This form of skin cancer is mostly caused by PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care, MBBS, Master in Healthcare Administration, Diploma in Occupational Health, What are the uses of Isosorbide Mononitrate. Ask your doctor before using aspirin together with alcohol. It will give you more information about nitrate medicines, and it will also provide you with a full list of side-effects which you could experience from taking isosorbide mononitrate. Alternative drugs to the conditions Isosorbide mononitrate treats: Angina High blood pressure Stable angina Chest pain Heart disease Heart attack Angina unstable Heart disease congenital Coronary heart disease Heart failure Pulse Heart rate irregular Coronary artery spasm Angioplasty Is isosorbide mononitrate (Monoket) the same as nitroglycerin (Nitrostat)? tell your doctor and pharmacist if you are allergic to isosorbide; nitroglycerin tablets, patches, or ointment; any other medications, or any of the ingredients in isosorbide tablets, extended-release tablets, or extended-release capsules. In: Current Medical Diagnosis & Treatment 2022. Isosorbide can only be used to prevent angina; it cannot be used to treat an episode of angina once it has begun. It works more slowly and lasts for about 12 hours, so you only need to take it once a day. If you have been told by a doctor you have low levels of iron in your blood (anaemia), or low levels of oxygen in your blood (hypoxaemia). Integrative medicine (complementary and alternative medicine). Dated October 2016. Isosorbide mononitrate is used to prevent chest pain ( angina) in patients with a certain heart condition ( coronary artery disease ). Copyright, 2023. Many people using this medication do not have serious side effects. 72% of reviewers reported a positive effect, while 12% reported a negative effect. Prescribed for Angina, Anal Fissure and Now, youll enjoy a streamlined experience created specifically for healthcare providers. Prescription and OTC Aspirin relieves pain and inflammation and helps to thin the blood. 2005 - 2023 WebMD LLC. Dehydration in Buspar, how severe and when it was recovered? It might help to take isosorbide mononitrate and dinitrate after meals. Isosorbide may cause other side effects. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. There may be variations in CSA schedules between individual states. Taking erectile dysfunction medications or drinking alcohol while taking isosorbide mononitrate (Monoket) can cause your blood pressure to get dangerously low, which can be life-threatening. WebMD does not provide medical advice, diagnosis or treatment. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). The dose is according to the body weight and severity of the condition. Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. 2023 eHealthMe.com. When used regularly on a long-term basis, this helps prevent angina attacks from occurring. Cleophas TJ, Niemeyer MG, van Der Wall EE. Nitroglycerin has an average rating of It does not have such side effects. Therefore, oral nitrates should not be used by patients who are sensitive to the effects of hypotension, such as those with pre-existing hypotension, shock, vascular collapse or significant cerebrovascular disease, significant anaemia or hypothyroidism. Call your doctor if you have any unusual problems while you are taking this medication. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Clin Res Cardiol. I strongly feel that there is coronary ischemia. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. In: Textbook of Natural Medicine. These headaches may be a sign that the medication is working as it should. Be sure to mention any of the following: aspirin; beta blockers such as atenolol (Tenormin, Tenoretic), carteolol , labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, in Dutoprol, in Lopressor HCT), nadolol (Corgard, in Corzide), propranolol (Hemangeol, Inderal, Innopran), sotalol (Betapace, Sorine, Sotylize), and timolol; calcium channel blockers such as amlodipine (Norvasc, in Amturnide, in Tekamlo), diltiazem (Cardizem, Cartia, Dilt-CD, others), felodipine (Plendil), isradipine, nifedipine (Adalat CC, Afeditab, Procardia), and verapamil (Calan, Covera, Verelan); ergot-type medications such as bromocriptine (Cycloset, Parlodel), cabergoline, dihydroergotamine (D.H.E. Nitrate-Induced Headache in Patients with Stable Angina Pectoris: Beneficial Effect of Starting on a Low Dosage. Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. Isosorbide mononitrate (Monoket) works slowly to help prevent chest pain. It is best not to drink alcohol while you are on isosorbide mononitrate. Commonly reported side effects include: See also: isosorbide mononitrate side effects in more detail. Keep this medication in the container it came in, tightly closed, and out of reach of children. The information contained in the Truven Health Micromedex products as delivered by GoodRx is intended as an educational aid only. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle. It is important that you follow the instructions your doctor gives to you about when to take your doses. May also be prescribed off label for Esophageal Spasm. Treatment and prognosis of heart failure with preserved ejection . Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Change positions slowly until your body is used to the medication. The effects of this exposure on a nursing infant are unknown. Your doctor will schedule your doses so that there is a period of time every day when you are not exposed to isosorbide. https://naturalmedicines.therapeuticresearch.com. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). This content does not have an English version. The Swedish Multicentre Group. This site needs JavaScript to work properly. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Use of herbal products and potential interactions in patients with cardiovascular diseases. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. In case of overdose, call the poison control helpline at 1-800-222-1222. Herbal supplements and heart medicines may not mix, Your blood pressure, if you also take a drug to treat high blood pressure, Beta blockers, such as atenolol (Tenormin), nadolol (Corgard) or propranolol (Inderal LA, Innopran XL), Calcium channel blockers, such as diltiazem, nifedipine (Procardia) and verapamil (Calan SR, Verelan), Nitrates, such as nitroglycerin (Nitrostat, Nitro-Dur, others) and isosorbide (Isordil, Bidil), Statins, such as atorvastatin (Lipitor), lovastatin (Altoprev) and rosuvastatin (Crestor), Anti-rejection medicine, also called immunosuppressant medicine, such as cyclosporine (Gengraf, Neoral, Sandimmune). The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. This medication performs a vasodilatory function and is therefore used as a treatment for high blood pressure. View more, Nitroglycerin dilates veins, relieving chest pain and lowering blood pressure. Hawthorn. ** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. This survey is being conducted by the WebMD marketing sciences department. Highly clinically significant. What should I know regarding pregnancy, nursing and administering Isosorbide Mononitrate to children or the elderly? No you may not. Before Isosorbide mononitrate is used to prevent chest pain in patients with a certain heart condition (coronary artery disease).This medication belongs to a class of drugs known as nitrates. Is not subject to the Controlled Substances Act. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. It works by relaxing and widening blood vessels so blood can flow more easily to the heart.This medication will not relieve chest pain once it occurs. This should pass after a few days. Isosorbide controls chest pain but does not cure coronary artery disease. 2023 Lybrate, Inc. All rights reserved. Isosorbide-5-mononitrate ISMN usually begins acting within 30 minutes and its effects last six to eight hours. Some people feel dizzy or fall when changing positions, such as going from sitting to standing. If you miss a dose, take it as soon as you remember. (3) The overall number of headache attacks in the first period of active treatment was significantly higher than in the second period irrespective of the dosages given. Longer-acting tablets and capsules are taken once daily in the morning. To use the sharing features on this page, please enable JavaScript. Anti-ischemic and anti-anginal effects of controlled-release and conventional isosorbide-5-mononitrate in stable angina pectoris. If we combine this information with your protected This side-effect usually disappears after a few days, Do not drive and do not use tools or machines while affected, If either of these becomes troublesome, speak with your doctor. It can cause your blood pressure to become dangerously low. Medicines containing Isosorbide Mononitrate. It took me a few weeks to adapt to it, but the effect on preventing chest pain was dramatic. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. All rights reserved. Be sure to talk to your health care provider before you take any herbal supplements if you take prescription medicines. This document does not contain all possible drug interactions. information highlighted below and resubmit the form. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Although not all of these side effects may occur, if they do occur they may need medical attention. Accessibility Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). The most common side-effect is headache. Herbal supplements are natural, so they must be safe, right? Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. National Library of Medicine What are the interactions of Isosorbide Mononitrate ? Federal government websites often end in .gov or .mil. These side effects may go away during treatment as your body adjusts to the medicine. There are no data on passage of isosorbide mononitrate in human milk, but some excretion seems likely. Avoid combinations; the risk of the interaction outweighs the benefit. People with kidney problems should be able to take the usual dose of isosorbide mononitrate (Monoket). Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. McGraw Hill; 2022. https://accessmedicine.mhmedical.com/search. Your provider might temporarily have you stop isosorbide mononitrate (Monoket) if this happens. Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). Your doctor will probably tell you not to take isosorbide if you are taking one of these medications. information submitted for this request. You may report side effects to the FDA at 1-800-FDA-1088. Which drugs or supplements interact with isosorbide mononitrate? If you become pregnant while taking isosorbide, call your doctor. Take your next dose at the regular time. Lyrica and Metoclopramide drug interaction, Calcitriol and Metoclopramide drug interaction. Natural Medicines. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Once- versus twice-daily administration of controlled-release isosorbide-5-mononitrate 60 mg in the treatment of stable angina pectoris. Egton Medical Information Systems Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. For haemoglobin formation vit. Of the total drug interactions, US residents can call their local poison control center at 1-800-222-1222. Continue to take isosorbide even if you feel well. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Ginkgo. If tolerance is suspected during the use of transdermal patches they should be left off for 8-12 hours (usually overnight) in each 24 hours; in the case of modified-release tablets of isosorbide dinitrate (and . Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. If you are taking other medicines, including those available to buy without a prescription, as well as herbal or complementary medicines. If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking. Pregnancy:Data on the use of isosorbide mononitrate during pregnancy are insufficient to be able to assess the possible harmful effect. Severe postural hypotension with light-headedness and dizziness is frequently observed after the consumption of alcohol. Registered in England and Wales. flushing - try to cut down on coffee, tea and alcohol because they can make flushing worse. Store it at room temperature and away from excess heat and moisture (not in the bathroom). 88 ratings on Drugs.com. Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. Some side effects may occur that usually do not need medical attention. 1996 Dec;3(12):802-806. doi: 10.1097/00045391-199612000-00003. Otherwise, call a poison control center right away. This content does not have an Arabic version. Isosorbide mononitrate (Monoket) is good for a specific type of chest pain (called angina), but it can cause headaches or dizziness after you take it. [2] If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. Use this medication regularly to get the most benefit from it. Elsevier; 2021. https://www.clinicalkey.com. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: continuing ringing or buzzing or other unexplained noise in the ears, dull ache or feeling of pressure or heaviness in the legs, excess air or gas in the stomach or intestines, increased sensitivity of the eyes to sunlight, loss in sexual ability, desire, drive, or performance, pain or tenderness around the eyes and cheekbones, redness of the face, neck, arms, and occasionally, upper chest, redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid, redness, swelling, or soreness of the tongue, small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope, stomach bloating, burning, cramping, or pain, terrifying dreams causing sleep disturbances, uncontrolled twisting movements of the neck, white patches in the mouth, tongue, or throat. Sept. 26, 2022. Discuss the risks and benefits with your doctor. In Canada - Call your doctor for medical advice about side effects. View more. It might help to keep the room cool and use a fan. Yet significantly fewer patients had headache on low dosage than on high dosage (45 vs 57, P < 0.02). Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Prescription and OTC A very serious allergic reaction to this drug is rare. This branded product is no longer on the market. AHFS Patient Medication Information. Aspirin relieves pain and inflammation and helps to thin the blood. AskMayoExpert. Do not stop taking isosorbide without talking to your doctor. If you have ever had an allergic reaction to a medicine. Does Viagra add to the risks of melanoma? The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 2021 May 11;39:28. doi: 10.11604/pamj.2021.39.28.22180. This does not necessarily mean no interactions exist. Take extra precautions to avoid falling during your treatment with isosorbide. Store at room temperature away from light and moisture. What special precautions should I follow? Isosorbide mononitrate (Monoket) is not a medication you take if you think you are having a heart attack. Modified-release nitrate preparations: use a once-daily dose to maintain a nitrate-low period and thus minimize tolerance. Try our Symptom Checker Got any other symptoms? This is because the tablets/capsules are specially made to release the medicine they contain in a controlled way. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less commonAcid or sour stomachanxietyback painbelchingblemishes on the skinbloatedbreast painburning feeling in the chest or stomachburning, dry, or itching eyeschange in color visionchanges in visioncold sweatscongestionconstipationcontinuing ringing or buzzing or other unexplained noise in the earscough producing mucusdecreased interest in sexual intercoursedifficulty seeing at nightdifficulty with movingdischarge, excessive tearingdouble visiondrooping upper eyelidsdull ache or feeling of pressure or heaviness in the legsearacheexcess air or gas in the stomach or intestinesfeeling of constant movement of self or surroundingsfeeling of warmthfeeling unusually coldfrequent urge to defecatefrozen shoulderfull feelinghearing lossheartburnhyperventilationinability to have or keep an erectionincreased appetiteincreased sensitivity of the eyes to sunlightincreased sputumindigestionirritabilityitching skin near damaged veinslack or loss of strengthloss in sexual ability, desire, drive, or performancemuscle or bone painmuscle stiffness or weaknessnightmaresnoisy breathingpain or tenderness around the eyes and cheekbonespassing gaspimplespoor concentrationrashredness of the face, neck, arms, and occasionally, upper chestredness, pain, swelling of the eye, eyelid, or inner lining of the eyelidredness, swelling, or soreness of the tonguerestlessnessseeing doublesensation of spinningsleepiness or unusual drowsinesssmall clicking, bubbling, or rattling sounds in the lung when listening with a stethoscopesmall lumps under the skinsore mouth or tonguestiff neckstomach bloating, burning, cramping, or painstomach discomfort or upsetstraining while passing stoolstuffy nosesudden sweatingswollen feet and anklestender, swollen glands in the necktenderness in the stomach areaterrifying dreams causing sleep disturbancestooth disordertrouble swallowinguncontrolled twisting movements of the neckvoice changesweight losswhite patches in the mouth, tongue, or throatOther side effects not listed may also occur in some patients.